Cerebral Palsy Spectrum Disorders Panel Test code: 55004 • 424 genes

Cerebral Palsy Spectrum Disorders Panel

This panel provides a broad genetic evaluation of genes that may help identify the underlying cause of cerebral palsy (CP) and related neurodevelopmental conditions. Cerebral palsy represents a heterogeneous group of conditions characterized by abnormalities in movement, muscle tone, and posture.

Because cerebral palsy and related neurological conditions can have multiple genetic and non-genetic causes, clinical features alone may not always be sufficient to determine the underlying etiology. Broad genetic testing allows for the evaluation of multiple potential genetic causes based on a single clinical indication.

The panel also includes genes associated with certain adult-onset neurological disorders, including:

• Hereditary spastic paraplegias (HSPs)
• Spinocerebellar ataxias (SCAs)
• Amyotrophic lateral sclerosis (ALS)
• Other related neurological conditions

The panel also includes the ATM gene, which is associated with ataxia-telangiectasia, an inherited disorder that can affect neurological and immune function. Individuals with ataxia-telangiectasia have an increased risk of certain malignancies, particularly leukemia and lymphoma.

Genetic testing may provide valuable information by helping to:

• Identify a potential underlying genetic cause
• Confirm or clarify a clinical diagnosis
• Distinguish between cerebral palsy and genetically related neurological conditions
• Guide medical management and appropriate monitoring
• Help assess potential disease-associated risks
• Inform genetic counseling and family planning
• Identify potentially affected relatives who may benefit from genetic testing
• Support appropriate surveillance for associated health complications

Genetic test results should be interpreted in conjunction with the individual's neurological findings, developmental history, medical history, family history, and other diagnostic evaluations.