Hereditary Breast and Gyn Cancers Guidelines-Based Panel 19 genes

Hereditary Breast and Gyn Cancers Guidelines-Based Panel 19 genes
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Hereditary Breast and Gynecologic Cancers Guidelines-Based Panel     19 genes

This panel analyzes genes associated with an increased predisposition to adult-onset breast, ovarian, uterine, fallopian tube, and peritoneal cancers for which medically actionable, evidence-based screening, management, and risk-reduction strategies are available.

Individuals with a hereditary predisposition to breast or gynecologic cancers may benefit from specialized and, in some cases, more intensive medical management. Genetic testing can help guide personalized cancer screening and risk-reduction strategies, including:

  • Determining the appropriate age to begin cancer screening

  • Establishing the recommended frequency and intervals between screenings

  • Identifying appropriate screening methods

  • Evaluating preventive and risk-reducing options, including surgery

  • Assessing the potential risk of developing additional primary cancers

  • Supporting earlier detection and intervention when appropriate

These strategies may help reduce cancer risk or facilitate earlier diagnosis, potentially improving treatment options and outcomes.

Because hereditary breast and gynecologic cancer conditions can have significant clinical overlap, broad panel testing allows for an efficient evaluation of multiple potential genes based on a single clinical indication. Some genes included in the panel may also be associated with additional medical conditions that are unrelated to hereditary breast or gynecologic cancer predisposition; these conditions are not included among the disorders specifically evaluated by this test.

Genetic testing may provide additional clinical value by helping to:

  • Confirm or clarify a clinical diagnosis

  • Assess hereditary cancer risk

  • Inform cancer screening and risk-reduction strategies

  • Help predict disease prognosis and progression

  • Support earlier detection and appropriate surveillance

  • Guide family planning and genetic counseling

  • Identify potentially affected relatives who may benefit from genetic testing

  • Support consideration for relevant clinical trials

Important Testing Information:
This panel is specifically designed to identify heritable germline genetic variants. It is not intended to detect somatic mutations in tumor tissue and should not be used as a substitute for tumor-based somatic testing.