Hereditary Pediatric Solid Tumors Panel

Pediatric Solid Tumors Panel                     49 genes
The Pediatric Solid Tumors Panel evaluates genes associated with the development of childhood-onset malignant and benign tumors occurring throughout the body. It is designed to assess both syndromic and non-syndromic hereditary conditions that may increase a child's susceptibility to developing solid tumors.

Because pediatric tumor predisposition conditions can have significant genetic heterogeneity and overlapping clinical features, symptoms, tumor type, and physical characteristics alone may not always be sufficient to determine the underlying genetic cause. Broad panel testing allows for an efficient evaluation of multiple potential genes based on a single clinical indication.

Some genes included in this panel may also be associated with additional medical conditions that are unrelated to pediatric solid tumor susceptibility. These additional conditions are not included among the disorders specifically evaluated by this test.

Genetic testing may provide valuable information by helping to:

• Confirm or clarify a clinical diagnosis

• Identify an underlying hereditary tumor predisposition

• Assess potential cancer risk

• Help predict disease prognosis and progression

• Support earlier detection and appropriate surveillance

• Inform family planning and genetic counseling

• Identify potentially affected family members

• Support consideration for relevant clinical trials

Important Testing Information:
This panel is specifically designed to identify heritable germline genetic variants. It is not intended to detect somatic mutations in tumor tissue and should not be used as a substitute for tumor-based somatic testing.